Manchester United interim manager Ralf Rangnick has confirmed that six senior players will miss the Chelsea clash.
Man United will welcome The Blues at Old Trafford on Thursday night in the Premier League and will look to bounce back to winning ways.
United had endured two massive defeats to Liverpool and Arsenal last week but will look to push for a response against Chelsea with a depleted squad.
Sancho was impressive against Arsenal and showed a glimpse of urgency after his cameo against Liverpool but he is set to be on the sidelines tomorrow night.
Pogba suffered a knee injury against Liverpool, Fred endured an injury early in the game against Everton.